Table 3.

Bi-variable and multi-variable Cox proportional hazard analysis for predictors of time to first line antiretroviral treatment failure among adult people living with HIV in public health facilities of Arba Minch Town, Southern Ethiopia, 2018

Co-variates	CHR (95% CI)	AHR (95% CI)	p-values
Sex
Male	1.39(0.85,2.28)	0.99 (0.57,1.74)	0.994
Female	1
Educational status
No education	0.67(0.36,1.23)*	1.26(0.31,5.05)	0.747
Primary education	1.61(1.02,2.54)*	1.41 (0.4, 4.99)	0.59
Secondary education	1.44(0.96,2.16)*	1.42 (0.42,4.81)	0.58
Tertiary education	1
Duration on ART (months)
<12	1.33(1.03,17)	0.94 (0.52,1.68)	0.824
≥12	1
Disclosure status
Disclosed	1
Not disclosed	2.62(1.49,4.62)*	1.98(1.03,3.79)	0.04**
History of Substance used
Yes	1.76(1.05,2.95)*	2.94(1.62,5.32)	0.001**
No	1
Time since HIV diagnosis (Years)
≤3 Years	2.15(1.56,2.97)*	2.19(1.01,4.79)	0.05**
>3Years	1
Baseline WHO clinical stage
Stage I or II	1
Stage III or IV	1.45(0.89,2.34)*	2.02 (1.02,4.00)	0.045**
Baseline functional status
Working	1
Ambulatory	1.61(0.87,2.98)*	1.04(0.49,2.19)	0.927
Bedridden	4.31(2.49,7.44)*	2.71(1.33,5.51)	0.006**
History of 01 at baseline
Yes	1.72(1.06,2.78)	2.37(1.23,4.19)	0.009**
No	1
Baseline Weight (kg)
≥50	0.85(0.64,1.12)*	0.64 (0.32,1.28)	0.25
<50	1
Baseline BMI(Kg/m2)
<18.5	3.11(1.92,5.04)*	3.78(1.99,7.17)	0.001**
≥18.5	1
Baseline CD4 Count
≥200cells/mm3	1
<200 cells/mm3	2.36(1.44,3.86)	1.99(1.05,3.75)	0.034**
Adherence level
Good	1
Fair	2.02(1.09,3.73)*	1.26 (0.62,2.56)	0.52
Poor	2.12(1.22,3.68)*	1.99(1.05,3.76)	0.035**
History of initial regimen substitution
Yes	2.15(1.69,2.74)*	1.26(0.93,1.69)	0.140
No	1

Note: Baseline refers to indicators at ART initiation,

^*p<0.25 which are candidate for multi-variable Cox regression model,

^**p-value ≤ 0.05 statistically significant, 1 indicate reference group, CI = confidence interval