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. 2019 Apr 5;10:598. doi: 10.3389/fimmu.2019.00598

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Copyright © 2019 Hayes, Rane, Scales, Meehan, Benson, Maroof, Schroeder, Tomura, Gozzard, Yates, Garside and Brewer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modeling the trafficking of DC between skin and draining lymph nodes. (A) Schematic of the mathematical model of dendritic cell migration. Dendritic cells in the foot pad (X) were photo-converted (X^*) and migrate to the lymph node at the rate μ, taking a fixed transit time τ. “Y” is the number of photo-converted DCs that accumulate in the dLN over time and are lost, either by death or egress, with the rate δ_Y. (B) Fits of the model to data, showing the observed and best-fit numbers of photo-converted DCs in draining lymph nodes for saline treatment (left-hand panel) and for alum/LPS treatment (right-hand panel).