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. 2019 Apr 5;10:598. doi: 10.3389/fimmu.2019.00598

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Copyright © 2019 Hayes, Rane, Scales, Meehan, Benson, Maroof, Schroeder, Tomura, Gozzard, Yates, Garside and Brewer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Parameter estimates for the best fitting model in which μ_alum = μ₀ + αte^−mt and μ_saline = μ₀. (A) the parameter estimates calculated from the mathematical model are shown. (B) The number of migratory cells identified in the draining lymph node at various times with (C) a schematic of the migration pattern observed over a 72 h period. (D) By combining the data generated from the experimental and mathematic approaches, it is predicted that the cells entering the tissue will follow the same rate of decay and the estimated kinetics of cell migration from the skin to the lymph node and antigen presentation are summarized.