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NRPS-catalyzed Dieckmann-type condensation for product release and tetramic acid formation. (A) Structure of the bacterial natural product Heat Stable Activating Factor (HSAF). (B) Role of the lone NRPS in tetramic acid formation including A domain-catalyzed activation and loading of l-Orn, C domain-catalyzed amide bond formation, and TE domain-catalyzed Dieckmann-type condensation to release the product from the NRPS.
