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. 2018 Feb 5;16(3):250–259. doi: 10.1038/cmi.2017.157

Figure 2.

Figure 2

The diversity of T-cell receptor δ-chain (TRD) is significantly reduced in lung carcinoma (LC) patients. (a) The D50 of the TRD and T-cell receptor γ-chain (TRG) repertoires in LC patients. (b) The unique complementary determinant region 3 (CDR3)/total CDR3 value of the TRD and TRG repertoires in LC patients. *P<0.05. (c) The scatter plot of the distribution of the top 50 CDR3 clones in LC patients. (d) The statistical analysis of the proportion of top 50 CDR3 sequences by clone size (>20%, >15%, >10%, >5%, >1%, >0.5%, >0.3%, >0.1%). *P<0.05, **P<0.01. (e) The frequency of the top 1, top 5 and top 10 CDR3 sequences in LC patients. **P<0.01. The left panel shows TRD, and the right panel shows TRG in (c–e). Mean values with error bars representing the±standard error (s.e.m.) are plotted, and the Bootstrapping analysis and Mann–Whitney U-test was used to analyze differences between groups.