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. 2018 Feb 5;16(3):250–259. doi: 10.1038/cmi.2017.157

Figure 6.

Figure 6

Specific features associated with the TCRδ chain repertoire effectively distinguished lung carcinoma (LC) patients. (a) Unexpected clustering results from the four selected parameters of the complementary determinant region 3δ (CDR3δ) repertoire that significantly differ between LC patients and healthy individuals. (b) Principal component analysis for the four selected parameters. Sample con-1 to con-7 represent seven control samples, and LC-1 to LC-7 represent samples from seven patients with lung cancer. Four selected parameters are unique: CDR3/total CDR3, top 1 CDR3 frequency, hTRDV1/hTRDV2 and top 50 CDR3 clonal size 1–10%/<10%.