Fig. 4.

hDC-SIGN transgenic mouse kidneys have lower TNF, IL-6, and TGF-β1 in the late phase of C. albicans infection. hDC-SIGN transgenic and littermate control mice were infected with 1 × 10⁵ of C. albicans intravenously. On days 2, 4, and 6 after infection, mice were perfused with PBS and the kidneys were collected. a Tnf, b Il6, c Il10, and d Tgfb1 transcripts were quantified by qPCR and normalized against Gapdh. Uninfected, n = 4–5; day 2, n = 6; day 4, n = 10 (littermate control) or 9 (hDC-SIGN Tg); day 6, n = 6. Data were pooled from two to four independent experiments. The bars represent the mean ± SEM. Data were analyzed by two-way ANOVA followed by Tukey post hoc test. *p < 0.05