Fig. 6.
Neutralizing TGF-β reduces C. albicans-induced renal fibrosis and fungal burden. C. albicans (1 × 105)-infected wild-type mice were given neutralizing anti-mouse TGF-β antibody (250 µg) or mouse IgG1 intraperitoneally on days 0 and 3 after infection. Mice were perfused with PBS and kidneys were collected on day 6. a, b The levels of a Kim1 and b Acta2 in the kidney were quantified by qPCR and normalized against Gapdh. The bars represent the mean ± SEM. c Fungal burdens in the kidneys were determined on day 6 after infection. mouse IgG1, n = 5, α-TGF-β Ab, n = 6. Data were analyzed by Student’s two-tailed t test. **p < 0.01, ***p < 0.001