Fig. 8.
Raf-1 and MAP kinase phosphorylation in the kidney of C. albicans-infected transgenic and control mice. hDC-SIGN transgenic and littermate control mice were infected with 1 × 105 of C. albicans intravenously. On day 6 after infection, mice were perfused with PBS and the kidneys were collected. Paraffin-embedded kidney sections were stained for phosphorylated forms of a Raf-1 (Ser338), b p38 (Thr180/Tyr182), c JNK (Thr183/Tyr185), and d ERK1/2 (Thr202/Tyr204). DAB was used as a substrate for color development (brown). Slides were counterstained with hematoxylin (blue). Original magnification, ×400. Scale bar = 50 µm