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. 2019 Apr 5;13:302. doi: 10.3389/fnins.2019.00302

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Copyright © 2019 Gómez-Pinedo, Galán, Matías-Guiu, Pytel, Moreno, Guerrero-Sola and Matías-Guiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BACE1 expression in the hippocampus. (A–C,F) displays the dentate gyrus/subgranular zone and CA1 in controls (D–F) shows the increased BACE1 expression in patients, located in the subgranular zone (E, arrow) and in areas with amyloid plaques (F, arrows). Increased BACE1 expression is observed in nine patients; the remaining three showed similar levels to those observed in controls (G). The graph in (H) expresses data as means, and shows significant differences (p < 0.05). Image G expresses data as means and graph H as means ± standard deviation. Scale bar: 50 μm.