Table 2.
Transmission-blocking activity of the AdHu5-Pfs25-prime/AAV1-Pfs25-boost immunization regimen.
| Group | Mean intensity ± SEM (oocysts per midgut) | Mean prevalence ± SEM (% infected mosquitoes) | TRA (%)a | TBA (%)b |
|---|---|---|---|---|
| SHORT-TERM (35 DAYS) | ||||
| AdHu5-AAV1 Pfs25 | 0.20 ± 0.04 | 10.41 ± 3.51 | 99.84* | 89.28* |
| AdHu5-AAV1 Luc | 125.17 ± 49.84 | 97.18 ± 2.15 | ||
| LONG-TERM (287 DAYS) | ||||
| AdHu5-AAV1 Pfs25 | 0.24 ± 0.03 | 12.72 ± 1.53 | 99.73* | 85.97* |
| AdHu5-AAV1 Luc | 87.24 ± 31.86 | 90.63 ± 5.67 | ||
a
Transmission-reducing activity (TRA) was calculated by comparison with the control group, and significant differences were assessed using a Mann–Whitney U-test (*p < 0.0001).
b
Transmission-blocking activity (TBA) was calculated by comparison with the control group, and significant differences were assessed using a Fisher's exact probability test (
*
p < 0.0001).