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. 2017 Aug 29;2:6. doi: 10.1186/s41199-017-0025-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — EGFR and receptor tyrosine kinase signaling in head and neck cancer. Resistance to EGFR inhibition may arise via signaling from redundant tyrosine kinases, such as HER family members, as well as downstream signaling activation. These may be important biomarkers predicting therapeutic response in head and neck cancer