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. 2019 Apr 11;19:352. doi: 10.1186/s12885-019-5536-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The HPV16 sequencing coverage and the corresponding HPV copy number across the 7.9 kb HPV genome in a HPV negative and a HPV positive tumor. Tumor 508 is HPV negative while tumor 655 is an example of an HPV positive tumor which has approximately ~ 10 HPV copies present. The x- axis represents the 7.9 kb of the HPV 16 genome with the concordant genes listed below; y – axis represents the HPV sequencing read coverage (left) and the corresponding HPV copy number based on the sequencing depth in each tumor (right)