Fig. 5.

HPV integration resulted in copy number increases or deletions in the human chromosome regions where HPV integration occurred. In tumor 601, HPV integrations occurred in the 12p13.31 which spans a ~ 43 kb region and it also causes 2–3 times copy number changes at the HPV integration sites in the related regions in the human chromosome. In tumor 688, HPV integration in the 7q36.3 results in a 3–4 times copy number increase in the human chromosome regions where HPV integration occurred. In 601 and 522, HPV integration in the 7q22.1 and 17p13.3 lead to the loss of human chromosome sequences