. 2018 Nov 12;27(3):389–399. doi: 10.1038/s41431-018-0294-0

Table 2.

Results nuclear morphology analysis of control- and published laminopathy fibroblasts

ID	LMNA variant^a	Other variant^a	% abnorm. nuclei	# total nuclei	# norm. nuclei	# abnorm. nuclei	type of abnormality^b
ID	LMNA variant^a	Other variant^a	% abnorm. nuclei	# total nuclei	# norm. nuclei	# abnorm. nuclei	B	HC	D	B+HC	B+D
1	p.(Lys32del)		10.67	300	268	32	19	4	8	1	0
2	p.(Tyr259*)		53.00	300	141	159	6	145	1	7	0
3	p.(Arg331Gln)		22.00	500	390	110	31	68	10	0	1
4	p.(Arg439Cys)		24.50	200	151	49	31	10	6	1	1
5	p.(Arg482Trp)		24.50	200	151	49	43	0	4	1	1
6	p.(Thr528Met)		13.50	800	692	108	29	50	18	11	0
7	p.(Thr528Met) + p.(Met540Thr)		39.80	1000	602	398	46	202	10	140	0
8	p.(Glu537Val_fs^*14)		30.00	200	140	60	11	13	26	7	3
9	p.(Gly607_656del)		14.12	500	438	62	38	10	11	2	1
10	None		3.33	300	290	10	4	4	1	1	0
11	None		4.33	300	287	13	11	0	2	0	0
12	None		4.67	300	286	14	11	0	3	0	0
13	None	SCN5A p.(Phe1617del)	6.00	300	282	18	8	3	3	4	0
14	None	SCN5A p.(Phe1617del)	5.67	300	283	17	3	7	6	1	0
15	None		5.33	300	284	16	11	0	5	0	0
16	None	MYH7 p.(Ala161Pro)	5.33	300	284	16	9	1	6	0	0
17	None		3.33	300	290	10	5	1	4	0	0

^aProtein change identified variant according to LMNA NG_008692.2 NM_170707.3; SCN5A NG_008934.1 NM_198056.2; MYH7 NG_007884.1 NM_00257.3)

^bType of abnormality: B, Blebs/herniations; HC, honeycomb-like structure; D, donut-like structures, or combinations of aforementioned