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Multiplex families with laterality defects and CHD. Families segregating variants in ACVR2B (a, dominant), NODAL (b, dominant), ZIC3 (c, X-linked), and SMAD2 (d, dominant) are shown. Shaded individuals are affected with a laterality defect. Presence (+) or absence (−) of variant is indicated for tested individuals. Accompanying numbers indicate LAT IDS (see Supplementary Table S2). Phenotypes are provided for affected individuals for whom a DNA sample was not available
