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. 2019 Apr 5;10:734. doi: 10.3389/fimmu.2019.00734

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Copyright © 2019 Le Luduec, Boudreau, Freiberg and Hsu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KIR2DL1-S1 expression and function in NKG2C⁺ compartments. (A) Differential KIR2DL1 allele frequencies in NKG2C⁺ NK cells. (B) Frequency of NKG2C⁻ and NKG2C⁺ NK compartments in HCMV⁺ healthy donors. (C) Frequency of KIR2DL1⁺ cells within the NKG2C⁻ and NKG2C⁺ NK cell compartments. (D) Responsiveness of KIR2DL1SP NK cells in NKG2C⁻ and NKG2C⁺ compartment, against 721.221. (E) Inhibition of KIR2DL1sp cells in NKG2C⁻ and NKG2C⁺ compartment, with 721.221-Cw4. (F) Frequency of KIR2DS1⁺ cells in NKG2C⁻ and NKG2C⁺ NK populations. (G) Cytotoxic responsiveness of KIR2DS1sp with 721.221-Cw4 cells. Unpaired Mann-Whitney test was used. Symbols represent individual samples (mean ± SEM). *p < 0.05, **p < 0.01, and ***p < 0.001.