Table 3.

Assessment of Knee Injury and Osteoarthritis Outcome Score subscale in patients with knee osteoarthritis

KOOS subscale*	Visit	Curcumin (N = 70)	Diclofenac (N = 69)	P valuem
Pain	Baseline	53.29 ± 5.70	53.15 ± 4.24	0.89
	Day 14	72.70 ± 4.89	73.69 ± 3.97	0.56
	Day 28	88.77 ± 5.62	90.38 ± 3.61	0.07
	Change at day 14	19.40 ± 2.89	20.55 ± 3.22	0.25
	Change at day 28	35.48 ± 4.07	37.23 ± 2.05	0.15
	P valuewc	<0.01	<0.01
Symptoms	Baseline	55.77 ± 6.00	55.87 ± 5.97	0.66
	Day 14	61.58 ± 5.65	61.93 ± 5.47	0.88
	Day 28	67.95 ± 5.86	69.13 ± 5.50	0.82
	Change at day 14	5.82 ± 3.81	6.06 ± 3.36	0.83
	Change at day 28	12.19 ± 5.28	13.26 ± 4.44	0.94
	P valuewc	<0.01	<0.01
Function in daily living	Baseline	58.45 ± 4.96	61.26 ± 5.24	0.21
	Day 14	77.67 ± 5.90	80.54 ± 6.10	0.05
	Day 28	94.58 ± 6.58	96.23 ± 2.71	0.49
	Change at day 14	19.22 ± 2.99	19.28 ± 2.38	0.55
	Change at day 28	36.13 ± 3.61	34.97 ± 5.05	0.34
	P valuewc	<0.01	<0.01
Function in sport and recreation	Baseline	44.86 ± 8.47	48.55 ± 7.58	<0.01
	Day 14	68.43 ± 5.81	71.88 ± 5.01	<0.01
	Day 28	89.14 ± 6.43	91.88 ± 4.38	<0.01
	Change at day 14	23.57 ± 4.27	23.33 ± 4.34	0.63
	Change at day 28	44.28 ± 6.44	43.33 ± 6.22	0.15
	P valuewc	<0.01	<0.01
Quality of life	Baseline	42.95 ± 5.31	41.91 ± 6.88	0.06
	Day 14	59.64 ± 6.08	59.15 ± 7.73	0.58
	Day 28	73.57 ± 7.46	72.26 ± 8.61	0.64
	Change at day 14	16.70 ± 8.22	17.23 ± 8.44	0.62
	Change at day 28	30.63 ± 10.16	30.35 ± 10.02	0.60
	P valuewc	<0.01	<0.01

*Higher score indicated better improvement.

Values are expressed in mean ± standard deviation

Abbreviations: KOOS Knee Injury and Osteoarthritis Outcome Score, m Mann–Whitney test (between the group), N number of patients in each group, wc Wilcoxon signed-rank test (within the group)

P <0.05 is considered a statistically significant difference. KOOS scale is from 0 to 100, where 0 indicates “Extreme Problem” and 100 indicate “No Problem”. Change in mean score at days 14 and 28 is calculated from baseline KOOS for each subscale