. 2017 Oct 3;1:16. doi: 10.1186/s41512-017-0016-z

Table 1.

Characteristics of population, predictors and outcome in the IPD meta-analysis on prediction of pre-eclampsia

Population	Pregnant women
Predictors	Maternal clinical characteristics at booking: Maternal characteristics: Age, BMI, height, weight, ethnicity, smoking, alcohol or substance misuse; Medical history: pre-existing chronic kidney disease, heritable thrombophilias, autoimmune disease such as systemic lupus erythematosus (SLE) and anti-phospholipid syndrome, type 1 and 2 diabetes and hypertensive diseases; Previous obstetric history: parity, previous pre-eclampsia, GDM, pregnancy interval more than 10 years, family history of pre-eclampsia, family history of cardiovascular disease, previous miscarriages, preterm birth, stillbirth or small for gestational age foetus; Current pregnancy: Multiple pregnancy, mode of conception, early pregnancy bleeding, MAP, systolic and diastolic blood pressure, SES, new partner, diet or exercise in pregnancy, urine dipstick, PCR, 24 h protein Biochemical markers (first or second trimester): PAPP-A, sflt-1, PlGF, AFP, HCG, soluble endoglin, CRP, Hyper triglyceridaemia and PAI-1 Ultrasound markers (first or second trimester): CRL, AC, expected foetal weight centile, Uterine and umbilical artery Doppler (resistance index, pulsatility index, unilateral or bilateral notching)
Outcomes	Primary outcomes: Early (<34 weeks), late (≥34 weeks) and any pre-eclampsia Secondary outcomes: Maternal complications: Eclampsia, HELLP syndrome, abruption, hepatic and renal failure, cortical blindness, pulmonary oedema, postpartum haemorrhage, DIC, preterm delivery, admission to HDU, maternal death, caesarean section, GDM Foetal and neonatal complications: Birth weight in Kg and centile, small for gestational age foetus, stillbirth, neonatal death, hypoxic ischemic encephalopathy, respiratory distress syndrome, septicaemia, admission to neonatal unit

Population

Pregnant women

Predictors

Maternal clinical characteristics at booking: Maternal characteristics: Age, BMI, height, weight, ethnicity, smoking, alcohol or substance misuse; Medical history: pre-existing chronic kidney disease, heritable thrombophilias, autoimmune disease such as systemic lupus erythematosus (SLE) and anti-phospholipid syndrome, type 1 and 2 diabetes and hypertensive diseases; Previous obstetric history: parity, previous pre-eclampsia, GDM, pregnancy interval more than 10 years, family history of pre-eclampsia, family history of cardiovascular disease, previous miscarriages, preterm birth, stillbirth or small for gestational age foetus; Current pregnancy: Multiple pregnancy, mode of conception, early pregnancy bleeding, MAP, systolic and diastolic blood pressure, SES, new partner, diet or exercise in pregnancy, urine dipstick, PCR, 24 h protein
Biochemical markers (first or second trimester): PAPP-A, sflt-1, PlGF, AFP, HCG, soluble endoglin, CRP, Hyper triglyceridaemia and PAI-1
Ultrasound markers (first or second trimester): CRL, AC, expected foetal weight centile, Uterine and umbilical artery Doppler (resistance index, pulsatility index, unilateral or bilateral notching)

Outcomes

Primary outcomes:
Early (<34 weeks), late (≥34 weeks) and any pre-eclampsia
Secondary outcomes:
Maternal complications: Eclampsia, HELLP syndrome, abruption, hepatic and renal failure, cortical blindness, pulmonary oedema, postpartum haemorrhage, DIC, preterm delivery, admission to HDU, maternal death, caesarean section, GDM
Foetal and neonatal complications: Birth weight in Kg and centile, small for gestational age foetus, stillbirth, neonatal death, hypoxic ischemic encephalopathy, respiratory distress syndrome, septicaemia, admission to neonatal unit