Table 2.
Comparisons of baseline choroidal morphology and changes at 3 months after PDT between groups
| Time | Layer of choroid | Mean ± SD (range) | Mean ± SD (range) | P value |
|---|---|---|---|---|
| Responders (n = 70) | Non-responders (n = 16) | |||
| Baseline | Total choroidal thickness (μm) | 297.6 ± 111.2 (100–554) | 226.9 ± 56.0 (109–330) | 0.001b |
| Choriocapillaris/Sattler’s layer thickness (μm) | 84.9 ± 37.2 (14–177) | 83.1 ± 24.3 (53–201) | 0.868c | |
| Haller’s layer thickness (μm) | 212.7 ± 87.5 (75–388) | 143.8 ± 50.7 (56–276) | < 0.001b | |
| Ratioa | 0.707 ± 0.088 (0.446–0.958) | 0.637 ± 0.148 (0.272–0.836) | 0.083b | |
| Luminal diameter of pachyvessel (μm) | 275.9 ± 93.6 (104–493) (n = 66) | 209.6 ± 31.0(169–275) (n = 16) | < 0.001b | |
| Choroidal vascularity | 0.682 ± 0.064 (0.524–0.812) | 0.596 ± 0.049 (0.514–0.690) | < 0.001c | |
| Change | Total choroidal thickness (μm) | − 33.0 ± 38.6 (−126- + 113) | − 10.4 ± 19.1 (−45- + 32) | 0.036c |
| Choriocapillaris/Sattler’s layer thickness (μm) | − 7.19 ± 24.3 (−63- + 71) | − 5.13 ± 15.2 (−32- + 21) | 0.746c | |
| Haller’s layer thickness (μm) | − 27.0 ± 40.5 (−118- + 74) | − 6.4 ± 24.3 (−60- + 37) | 0.012c | |
| Ratioa | 0.006 ± 0.95 (−0.198- + 0.271) | 0.004 ± 0.082 (−0.131- + 0.150) | 0.946c | |
| Luminal diameter of pachyvessel (μm) | − 60.3 ± 40.6 (−195- + 38)(n = 66) | − 20.1 ± 25.2 (−84- + 18)(n = 16) | < 0.001c | |
| Choroidal vascularity | − 0.058 ± 0.049 (−0.280–0.026) | 0.004 ± 0.039 (−0.080–0.082) | < 0.001c | |
| Non-recurrent eyes (n = 44) | Recurrent eyes (n = 26) | |||
| Baseline | Total choroidal thickness (μm) | 290.1 ± 99.3 (100–479) | 310.3 ± 130.1(155–554) | 0.500b |
| Choriocapillaris/Sattler’s layer thickness (μm) | 80.8 ± 36.9 (14–177) | 91.7 ± 37.5 (31–167) | 0.240c | |
| Haller’s layer thickness (μm) | 209.3 ± 78.8 (76–375) | 218.5 ± 101.9 (75–388) | 0.693b | |
| Ratioa | 0.718 ± 0.082 (0.556–0.958) | 0.689 ± 0.096 (0.446–0.830) | 0.176c | |
| Luminal diameter of pachyvessel (μm) | 267.6 ± 86.4 (104–493) (n = 41) | 289.5 ± 104.8 (121–473) (n = 25) | 0.385c | |
| Choroidal vascularity | 0.685 ± 0.066 (0.524–0.812) | 0.676 ± 0.064 (0.557–0.782) | 0.557c | |
| Change | Total choroidal thickness (μm) | − 37.5 ± 28.5 (−126- + 2) | − 25.9 ± 50.4 (−125- + 113) | 0.294c |
| Choriocapillaris/Sattler’s layer thickness (μm) | − 7.2 ± 24.5 (−63- + 71) | − 7.2 ± 24.5 (−51- + 44) | 0.993b | |
| Haller’s layer thickness (μm) | − 31.8 ± 34.3 (−118- + 37) | − 18.8 ± 48.9 (−117- + 74) | 0.195c | |
| Ratioa | − 0.002 ± 0.092 (−0.198- + 0.261) | 0.020 ± 0.099 (−0.103- + 0.271) | 0.341b | |
| Luminal diameter of pachyvessel (μm) | − 61.2 ± 39.3 (−195--2) (n = 41) | − 58.7 ± 43.4 (−128- + 38) (n = 25) | 0.808c | |
| Choroidal vascularity | − 0.049 ± 0.042 (−0.142–0.026) | − 0.073 ± 0.058 (−0.281--0.003) | 0.097c |
SD standard deviation
aRatio of Haller’s layer thickness to total choroidal thickness
bStudent’s t-test between groups
cMann–Whitney test between groups