Table 1.
CD73 expression on various cell types and tissues and its prognostic finding.
| Cell type | Tissue or cell type | Origin | Reported prognostic finding | References |
|---|---|---|---|---|
| Monocyte | Peripheral blood post-infarcted myocardium | Human Swine | Mesenchymal Stem Cells Induce Expression of CD73 in Human Monocytes in vitro and in a Swine Model of myocardial Infarction in vivo. Positive ADO loop leads to attenuation of inflammation and promotes the regeneration of the damaged myocardial tissue |
(156) |
| Monocytes in the inflamed joint | Murine | CD73 expression is associated with the suppression of inflammation in rheumatoid arthritis | (157) | |
| Neutrophil | Neutrophils in the inflamed joint | Murine | CD73 expression is associated with the suppression of inflammation in rheumatoid arthritis | (157) |
| Dendritic cell | Skin | Murine | Production of Extracellular Adenosine by CD73+ Dendritic Cells Is Crucial for Induction of T cell Anergy and Tolerance in Contact Hypersensitivity Reactions | (158) |
| MDSC | MDSCs generated from mouse hematopoietic progenitor cells (in vitro) | Murine | Generation of ADO by CD73 may promote MDSC expansion and facilitate their immunosuppressive activity | (159) |
| Peripheral Blood from advanced melanoma patients | Human | High baseline levels of CD73 on MDSCs negatively correlate with Overall Survival and Progression Free Survival | (160) | |
| Macrophage | Alveolar macrophages | Murine | CD73 expression in the lung tissue contributes to radiation-induced lung fibrosis | (138) |
| Peritoneal macrophages | Murine | CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages and is required to limit neutrophil influx in a peritonitis model | (161) | |
| NK cells | Peripheral blood 2–5% CD73+ NK cells | Human | ADO induces T cell suppression | (162–164) |
| Upregulation of CD73 upon exposure to MSC (in vitro) | Human | CD73+ NK cells have the potential to regulate NK cell activation in an autocrine or paracrine manner | (165) | |
| B cells | Subpopulations of murine memory B cells, germinal center B cells | Murine | ADO signaling is prominent in the mature germinal center and required for establishment of the long-lived plasma cell compartment | (166) |
| Peripheral blood and tonsil | Human |
Dependence of Immunoglobulin Class Switch Recombination in B Cells on Vesicular Release of ATP and CD73 Ectonucleotidase Activity Common variable immunodeficiency (CVID) patients with impaired class-switched antibody responses are selectively deficient in CD73 |
(167) | |
| Colon B cells | Murine | B cell CD73/CD39/adenosine mediates immunosuppression in DSS-induced colitis | (149) | |
| T cells | Th1, Th2, Th17, Treg in normal, and tumor tissues | Murine human | CD73 may favor cell homeostasis, memory survival, and differentiation | (168–170) |
| Human | CD73+ T cells infiltrate into breast and ovarian tumor tissue | (165) | ||
| Human murine | ADO induces immunosuppression | (146, 171–174) | ||
| Murine | CD73 expression on extracellular vesicles derived from Treg contributes to their regulatory function | (175) | ||
| Murine | CD73 expression in the lung tissue contributes to radiation-induced lung fibrosis | (138) | ||
| Fibroblasts | Cancer-associated fibroblasts in High-grade serous ovarian cancer (HGSC) | Human | High CD73 expression on CAFs is associated with worse prognosis | (176) |
| Cancer-associated fibroblasts in bladder cancer | Human | High CD73 expression on CAFs is associated with worse prognosis | (177) | |
| Epithelial cells | Retinal pigment epithelial cells | Murine | CD73 expression is associated with the suppression of conventional CD4 cell proliferation | (178) |
| Renal epithelial cells | Murine | CD73 expression on proximal tubular epithelial cells Is critical in renal ischemia-reperfusion injury protection | (179) | |
| Endothelial cells | Bladder cancer | Human | High CD73 expression is associated with better survival in non-muscle-invasive BC (NMIBC) and muscle-invasive BC (MIBC) tumors | (177) |
| Mesenchymal stem cells (MSC) | Experimental autoimmune uveitis (EAU) | Murine | Inhibition of T-cell proliferation | (150) |
| Stem cells (Hematopoitic stem cells; cancer stem cells) | Murine human | CD73/Ado induce stemness, homing | (151, 154) |