Table 1.
No. of contacts | Observed pyrs | No. of TB disease cases | Cumulative incidence /100,000 | 95% CI | P | Incidence density /100,000 pyrs | Adjusted incidence density /100,000 pyrsb | 95% CI | P | |
---|---|---|---|---|---|---|---|---|---|---|
8137 | 20,991 | 69 | 848 | 660–1071 | – | 329 | – | – | – | |
Sex | ||||||||||
male | 3792 | 9768 | 44 | 1160 | 844–1555 | 0.005 | 450 | 462 | 336–616 | 0.009 |
female | 4345 | 11,223 | 25 | 575 | 373–848 | 223 | 236 | 158–350 | ||
Age (years) | ||||||||||
1–9 | 436 | 1103 | 2 | 459 | 56–1647 | 0.195 | 181 | 184 | 22–653 | 0.18 |
10–19 | 529 | 1402 | 7 | 1323 | 534–2707 | 499 | 469 | 201–1026 | ||
20–29 | 1992 | 5099 | 25 | 1255 | 814–1847 | 490 | 490 | 318–723 | ||
30–39 | 1371 | 3592 | 6 | 438 | 161–950 | 167 | 161 | 61–363 | ||
40–49 | 1544 | 4033 | 16 | 1036 | 593–1677 | 397 | 402 | 227–643 | ||
50–59 | 1176 | 3023 | 8 | 680 | 294–1336 | 265 | 272 | 114–521 | ||
60–69 | 635 | 1587 | 2 | 315 | 38–1133 | 126 | 160 | 39–551 | ||
70–79 | 309 | 819 | 2 | 647 | 78–2318 | 244 | 450 | 133–1246 | ||
80–89 | 133 | 310 | 1 | 752 | 19–4118 | 323 | 542 | 78–2318 | ||
≥ 90 | 12 | 23 | 0 | 0 | – | 0 | 0 | – | ||
Type of index case | ||||||||||
Smear+ | 5953 | 16,127 | 50 | 840 | 624–1106 | 0.892 | 310 | 327 | 246–430 | 0.217 |
Smear- | 2184 | 4864 | 19 | 870 | 525–1355 | 391 | 456 | 284–684 | ||
Bacterial+ | 7527 | 19,870 | 67 | 890 | 690–1129 | 0.172 | 337 | 348 | 270–439 | 1.000 |
Bacterial- | 610 | 1121 | 2 | 328 | 40–1179 | 178 | 239 | 55–780 | ||
Relationship with index case | ||||||||||
None-relatives | 1175 | 2915 | 9 | 766 | 351–1449 | 0.139 | 309 | 180 | 56–400 | 0.008 |
Wife/husband | 1561 | 4057 | 12 | 769 | 398–1339 | 296 | 283 | 153–516 | ||
Parents/children | 2728 | 7267 | 30 | 1100 | 743–1566 | 413 | 487 | 336–669 | ||
Other relatives | 2364 | 5920 | 13 | 550 | 293–939 | 220 | 205 | 105–354 | ||
sibling | 309 | 832 | 5 | 1618 | 527–3736 | 601 | 567 | 195–1397 | ||
Biologically related family a | 3037 | 8099 | 35 | 1152 | 804–1599 | 0.021 | 432 | 475 | 332,643 | 0.031 |
Other relationship | 5100 | 12,892 | 34 | 667 | 462–930 | 264 | 281 | 196–386 |
aBiologically related family: parents/children and siblings
bIncidence density adjusted by age and gender