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. 2016 Oct 1;1:12. doi: 10.1186/s41199-016-0013-x

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The Immune Synapse. The balance between costimulatory (green) and coinhibitory signals (red) alters the net stimulating effect of TCR signaling mediated through antigen presentation on MHC (blue). Adapted from Ferris RL, J Clin Oncol. 2015;33(29):3293–304