Table 5.
Summary diagnostic accuracy of LUS in different diseases
| Disease | Study no. | Numbers | Sensitivity (95% CI) | Heterogeneity | Specificity (95% CI) | Heterogeneity | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC (SE) | Q* (SE) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ILD (+) | ILD (−) | I 2 | p value | I 2 | p value | |||||||||
| SSc | 6 | 170 | 87 | 0.839 (0.777–0.889) | 78.3 | 0 | 0.870 (0.774–0.936) | 21.4 | 0.272 | 6.203 (3.565–10.800) | 0.191 (0.098–0.373) | 42.93 (17.75–103.79) | 0.929 (0.024) | 0.864 (0.029) |
| RA | 3 | 37 | 91 | 0.946 (0.818–0.993) | 0 | 0.636 | 0.824 (0.730–0.896) | 91.8 | 0 | 7.398 (0.768–74.220) | 0.082 (0.024–0.275) | 80.24 (8.107–796.09) | 0.9810 (0.014) | 0.939 (0.027) |
CTD connective tissue disease, ILD interstitial lung disease, SSc systemic sclerosis, RA rheumatoid arthritis, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic OR, AUC area under the curve, CI confidence interval, SE standard error, − not available