Table 2.
Top ten pathways showing significantly altered transcription as identified by Ingenuity Pathway Analysis (Qiagen). Arrows indicate expression in DE samples compared to FA
| Ingenuity Canonical Pathway | p-value | Molecules |
|---|---|---|
| Mitochondrial L-carnitine Shuttle Pathway | 2.14E-06 | ↓Slc27a1, Acsl1, Cpt1A, Cpt2, Cpt1B |
| Fatty Acid β-oxidation | 3.47E-06 | ↓Slc27a1, Acaa2, Acsl1, Hadha, Eci2, Hadhb |
| AMPK Signaling | 4.68E-06 | ↓Mlycd, Adra1B, Pik3r3, Cpt1A, Acacb, Lipe, Cpt2, Cpt1B ↑Adra2a, Ccnd1, Pfkl, Slc2a1 |
| Cell Cycle Control of Chromosomal Replication | 2.51E-05 | ↑Cdc45, Mcm2, Mcm3, Mcm6, Mcm5 |
| LPS/IL-1 Mediated Inhibition of RXR Function | 4.17E-05 | ↓Slc27a1, Hmgcs2, Aldh9a1, Acsl1, Ppargc1b, Fabp3, Cat, Cpt1A, Cpt2, Cpt1B ↑Chst12, Fabp5 |
| GADD45 Signaling | 1.00E-04 | ↑Ccne1, Ccnd1, Pcna, Cdk1 |
| Hepatic Fibrosis / Hepatic Stellate Cell Activation | 1.70E-04 | ↑A2m, Igfbp4, Pgf, Col27a1, Col5a3, Igfbp3, Col1a1, Ccl21 ↓Fgf1, Myh6 |
| Ketogenesis | 2.57E-04 | ↓Hmgcs2, Hadha, Hadhb |
| Estrogen-mediated S-phase Entry | 2.57E-04 | ↑Ccne1, Ccnd1, E2f1, Cdk1 |
| Oleate Biosynthesis II (Animals) | 5.89E-04 | ↓Scd4 ↑Fads1 |