Table 3.
Comparison of significant pathways from the RNA-seq dataset using gene set tests on GSE14288, a microarray analysis of mouse neonatal cardiomyocytes overexpressing CHF1/Hey2 and treated with serum to induce hypertrophy. The # Genes column reflects the number of genes in the microarray data that were tested, and the FDR is the Benjamini-Hochberg adjusted p-value for the test that, on average, the genes in the set are differentially expressed
| Ingenuity Canonical Pathway | # Genes | FDR |
|---|---|---|
| Mitochondrial L-carnitine Shuttle Pathway | 11 | 5.92E-06 |
| Fatty Acid β-oxidation | 23 | 6.26E-15 |
| AMPK Signaling | 566 | 1.02E-23 |
| Cell Cycle Control of Chromosomal Replication | 48 | 4.64E-16 |
| LPS/IL-1 Mediated Inhibition of RXR Function | 169 | 2.31E-30 |
| GADD45 Signaling | 24 | 1.00E-08 |
| Hepatic Fibrosis/Hepatic Stellate Cell Activation | 179 | 3.68E-20 |
| Ketogenesis | 8 | 1.46E-06 |
| Estrogen-mediated S-phase Entry | 44 | 1.01E-19 |
| Oleate Biosynthesis II (Animals) | 8 | 3.56E-06 |