Table 5.
Top ten pathways with altered DNA methylation. All molecules listed have shown decreased methylation in the associated DMRs
| Ingenuity Canonical Pathway | p-value | Molecules |
|---|---|---|
| Cardiac Hypertrophy Signaling | 0.002 | Map3k9, Gnas, Adra2c, Gng12 |
| Gαs Signaling | 0.002 | Rapgef2, Gnas, Gng12 |
| G Protein Signaling Mediated by Tubby | 0.003 | Gnas, Gng12 |
| Gαi Signaling | 0.003 | Gnas, Adra2c, Gng12 |
| Cardiac β-adrenergic Signaling | 0.004 | Gnas, Gng12, Pde6h |
| Relaxin Signaling | 0.004 | Gnas, Gng12, Pde6h |
| Ephrin Receptor Signaling | 0.008 | Epha7, Gnas, Gng12 |
| CCR5 Signaling in Macrophages | 0.012 | Gnas, Gng12 |
| Ephrin B Signaling | 0.013 | Gnas, Gng12 |
| Protein Kinase A Signaling | 0.014 | Ptpru, Gnas, Gng12, Pde6h |