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. 2019 Apr 11;16:16. doi: 10.1186/s12989-019-0300-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effects of SiNPs on vascular oxidative damage, NO/NO system and vascular function. The level of MDA (a) was increased, while the activities of SOD (b) and GSH-Px (c) were decreased in a dose dependent manner. The activity of NO (d) and eNOS (f) decreased markedly and the activity of iNOS (e) increased with increasing SiNPs. Effect of SiNPs on tissue factor (TF) expression in aortic arch sections were detected by immunohistochemical analysis (g). Expression of TF increased in a dose-dependent manner by SiNPs (h). Data were expressed as means ± S.D. from six independent experiments. *p < 0.05 and **p < 0.01 compared with control without SiNPs and any mimics/inhibitor