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. 2017 Nov 15;1:17. doi: 10.1186/s41512-017-0017-y

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Multivariable modelling. Two possible prognostic test permutations for pre-eclampsia prediction in first-time pregnant women are shown (hypothetical data) (a). Rule-in test compliant with pre-set test specification: PPV ≥ 0.133, S _n ≥ 0.50, for a 5% disease prevalence. b Rule-out test compliant with pre-set test specification: NPV ≥ 0.988, S _p ≥ 0.50, for a 5% disease prevalence