Table 3.
Positively selected genes associated with mitochondrial biogenesis identified in a meta-analysis across three evolutionary clades with exceptional short or long lifespans
| Gene symbol | p-value | FDRd | |||
|---|---|---|---|---|---|
| Clownfish LCAa | Nothobranchius b | Mole-ratb | Combinedc | ||
| MTERF1 | 7.34E-03 | 1.25E-03 | 2.57E-02 | 3.12E-05 | 4.01E-04 |
| RARS2 | 1.82E-03 | 1.18E-02 | NAe | 2.52E-04 | 2.43E-03 |
| MRPL30 | 2.55E-02 | 1.00E+ 00 | 9.59E-03 | 2.28E-03 | 7.98E-03 |
| FASTKD2 | 1.77E-04 | 1.56E-01 | 1.00E+ 00 | 3.16E-04 | 2.43E-03 |
| FASTKD5 | NAe | 1.39E-03 | 8.25E-01 | 8.89E-03 | 2.44E-02 |
| TFB2M | NAe | 4.34E-04 | 6.91E-01 | 2.73E-03 | 9.15E-03 |
| NDUFA9 | NAe | 8.31E-02 | 6.90E-03 | 4.85E-03 | 1.56E-02 |
a LCA – last common ancestors
b These p-values resulted from meta-analysis using Fisher’s method of 3 ancestral Nothobranchius and 11 examined mole-rat branches on which lifespan changed considerably
c This p-value results from a meta-analysis of the three p-values in the left columns using Fisher’s method
d FDR – false discovery rate (adjusted p-value for multiple testing)
e NA – no p-value calculated since the gene could not be tested in the respective context