Table 1.
Descriptive Statistics of FHS individuals tested for interaction between genetics and plasma lipids on risk of AD.
| Variable | AD Cases | Controls | p-value* |
|---|---|---|---|
| N | 157 | 2883 | |
| Female | 99 (63%) | 1566 (54%) | 0.032 |
| Age | 52.0±3.0 | 51.3±2.8 | 0.005 |
| Offspring Cohort | 105 (67%) | 2367 (82%) | <.0001 |
| Follow-up time | 13.9±4.4 | 11.3±6.6 | <.0001 |
| HDL-C | 54.4±18.0 | 52.6±16.3 | 0.180 |
| LDL-C | 148.3±39.9 | 138.4±36.4 | 0.001 |
| Triglycerides | 203.4±198.2 | 172.5±174.6 | 0.013** |
| % on lipid lowering treatment | 2 (1%) | 73 (3%) | 0.320 |
| Systolic Blood Pressure | 124.5±14.4 | 125.6±16.9 | 0.434 |
| Body Mass Index (BMI) | 26.0±4.0 | 26.7±4.5 | 0.093 |
| Type 2 Diabetes | 6 (4%) | 96 (4%) | 0.745 |
| Stroke | 22 (14%) | 303 (11%) | 0.167 |
| Coronary Heart Disease | 34 (22%) | 673 (23%) | 0.626 |
Continuous variables displayed as mean±standard deviation and categorical variables are displayed N (percentage).
*
p-value comparing cases and controls using a two-sample t-test for continuous variables and a chi-square test for categorical variables
**
p-value for log(triglycerides)