. Author manuscript; available in PMC: 2019 Apr 12.

Published in final edited form as: J Alzheimers Dis. 2018;66(3):1275–1282. doi: 10.3233/JAD-180751

Table 2.

Interactions between AD GRS and lipid levels on AD status in up to 3039 FHS individuals.

Lipid Interactor	N Cases	N Total	Beta	SE	pval
Continuous lipid level
HDL-C	156	2995	0.005	0.007	0.458
LDL-C	156	2995	−0.002	0.002	0.366
Log (triglycerides)	157	3039	−0.353	0.129	0.006

Extreme lipid level categorized by sex-specific 5^th-percentiles of NHANES data
Low HDL-C	156	3031	0.168	0.314	0.593
High LDL-C	156	2995	−0.157	0.243	0.518
High triglycerides	157	3039	−0.573	0.254	0.024
Extreme lipid level categorized by ATP III clinical definitions

Low HDL-C	157	3040	0.011	0.224	0.960

High LDL-C	156	2995	−0.043	0.303	0.887

High triglycerides	157	3039	−0.655	0.223	0.003