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. Author manuscript; available in PMC: 2019 Apr 12.
Published in final edited form as: Adv Cancer Res. 2018 Jun 20;140:265–293. doi: 10.1016/bs.acr.2018.04.014

Figure 2. Inhibitors of sphingolipid metabolism.

Figure 2

Inhibitors of DES promote autophagy and growth inhibition. Drugs that target sphingolipid metabolism downstream of ceramide have the potential to result in accumulation of ceramide to promote cell death and/or to prevent sphingosine 1-phosphate (S1P)emediated survival signaling. Details of the inhibitors shown are discussed in the text. ROME, (R)-FTY720 methyl ether; SK1, sphingosine kinase 1.