Figure 4.

Schematic of the β-catenin-lymphoid enhancer-binding factor/T cell factor (LEF/TCF) signal pathway that regulates peripheral neuron regeneration by APC knockdown. There is normally interaction of APC with AXIN and GSK3 that phosphorylates β-catenin to be rapidly degraded by the ubiquitin proteasome. In the absence or knockdown of APC signal with an altered AXIN-GSK3β complex, β-catenin accumulates and forms a complex with LEF/TCF in the nucleus, which initiates transcription of downstream target genes, in turn to promote regeneration (Duraikannu, original illustration).