Table 1.
A selected listing of approaches discussed in this review that promote axonal regeneration.
Neurotrophic factors |
Nerve growth factor (NGF) |
Brain derived neurotrophic factor (BDNF) |
Neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) |
Ciliary neurotrophic factor (CNTF) |
Leukemia inhibitory factor (LIF) |
Oncostatin M (OSM) |
Glial cell line-derived neurotrophic factor (GDNF) |
Hepatocyte growth factor (HGF) |
Cardiotrophin-1 (CT-1) |
Neurturin (NRTN) |
Artemin (ARTN) |
Persephin (PSP) |
Bone morphogenetic proteins (BMPs) |
Epidermal growth factor (EGF) |
Fibroblast growth factor (FGF) |
Osteopontin (OPN) |
Insulin |
Electrical stimulation |
Developmental molecules in regeneration |
Unc5H inhibition |
Growth cone manipulation |
Inhibition of RHOA-ROK |
Influence of tumor suppressor pathways during regeneration |
Phosphatase and tensin homolog (PTEN) |
Retinoblastoma 1 (Rb1) |
APC-β-catentin pathway |