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T cell repertoire study. Spectratyping of CD3+ T cells for TCRβ was performed for patient B. The patient has essentially absent TCRVβ repertoire diversity (Cellular and Molecular Immunology Laboratory, Mayo Clinic). The majority of the 23 Vβ families assessed are completely absent and those that show the presence of T cell receptor Vβ families are profoundly oligoclonal (≤5 independent peaks). Patient in red, house-keeping gene (β-actin) in blue, and size marker in orange.
