Supplementary Table 1.

Comparison of the allele frequencies of each SNP among discovery, replication and validation samples.

SNP	Genotype	Discovery set (N=367)	Replication set (N=758)	Validation set (N=316)
rs10893585	CC	29.1%	34.2%	30.1%
	CT	48.4%	47.3%	52.3%
	TT	22.5%	18.5%	17.6%
	HWE	0.583	0.401	0.277
rs2431	AA	12.8%	17.7%	12.7%
	AG	45.5%	43.1%	44.8%
	GG	41.7%	39.2%	42.5%
	HWE	0.892	0.009	0.757
rs34675408	GT	7.7%	6.4%	7.8%
	TT	92.3%	93.6%	92.2%
	HWE	0.446	0.365	0.475
rs6078460	AA	57.4%	52.9%	56.2%
	AG	37.0%	38.6%	38.2%
	GG	5.6%	8.4%	5.6%
	HWE	0.808	0.310	0.617
rs6766361	AA	6.3%	7.9%	5.2%
	CA	39.5%	39.1%	39.5%
	CC	54.2%	52.9%	55.2%
	HWE	0.639	0.624	0.341

SNP – single nucleotide polymorphisms; HWE – Hardy-Weinberg equilibrium.