Supplementary Table 3.

Patient characteristics and distributions of immunoreactive scoring (IRS) by immunohistochemical staining of FNDC3B in 361 HCC tumor tissues on tissue microarrays.

Variable	Number	IRS ≤1.5	IRS>1.5	P-value*
Total
Deceased	193	133	60	0.027
Alive	168	133	35
MST, months	76.2	87.1	48.0
Gender
Male	298	211	87	0.007
Female	63	55	8
Age, years
≤55	231	162	69	0.041
>55	130	104	26
AFP, ng/ml
≤20	135	101	34	0.706
>20	226	165	61
ALT, ng/ml
≤75	316	234	82	0.675
>75	45	32	13
Tumor size, cm
≤5	276	214	62	0.003
>5	85	52	33
Tumor number
Single	339	249	90	0.693
Multiple	22	17	5
Vascular invasion
Yes	117	78	39	0.036
No	244	188	56
Extrahepatic metastasis
Yes	5	5	0	0.178
No	356	261	95
TNM stage
I–II	296	227	69	0.006
III–IV	65	39	26
Tumor differentiation
I–II	272	205	67	0.184
III–IV	88	60	28
Liver cirrhosis
Yes	79	63	16	0.170
No	279	201	78
Tumor encapsulation
None	186	136	50	0.801
Complete	175	130	45
HBsAg
Positive	331	244	87	0.801
Negative	29	22	7
HBcAb
Positive	340	249	91	0.244
Negative	20	17	3
Anti-HCV
Positive	2	1	1	0.444
Negative	356	263	93

Owing to a lack of information for some samples, the number of participants in each category may not add up to the total number. HCC – hepatocellular carcinoma; AFP – alpha-fetoprotein; ALT – alanine aminotransferase; CI – confidence interval; HBsAg – hepatitis B surface antigen; HBcAb – hepatitis B core antibody; HCV – hepatitis C virus; HR – hazard ratio; TNM – tumor node metastasis.

^*χ² – test between different IRS groups and clinical variables.