Supplementary Table 6.
Multivariate Cox regression analyses of each SNP (rs10893585, rs2431, rs34675408, rs6078460, and rs6766361) for overall survival of HCC samples combined discovery and replication sets (n=1125).
| Variable | P-value | HR | 95.0% CI for HR | |
|---|---|---|---|---|
| Lower | Upper | |||
| For rs10893585 | ||||
| AFP, ng/ml (>20 vs. ≤20) | 0.019 | 1.249 | 1.037 | 1.504 |
| Tumor size, cm (>5 vs. ≤5) | 9.63×10−10 | 2.162 | 1.689 | 2.768 |
| Tumor number (multiple vs. single) | 0.010 | 1.340 | 1.073 | 1.675 |
| Vascular invasion (yes vs. no) | 7.72×10−10 | 1.987 | 1.596 | 2.473 |
| Extrahepatic metastasis (yes vs. no) | 5.35×10−3 | 1.699 | 1.170 | 2.467 |
| Tumor differentiation (III–IV vs. I–II) | 0.011 | 1.262 | 1.056 | 1.508 |
| Tumor encapsulation (none vs. complete) | 1.25×10−4 | 1.412 | 1.184 | 1.683 |
| Genotype (CC vs. CT+TT) | 0.019 | 0.802 | 0.667 | 0.964 |
| For rs2431 | ||||
| AFP, ng/ml (>20 vs. ≤20) | 0.032 | 1.227 | 1.018 | 1.478 |
| Tumor size, cm (>5 vs. ≤5) | 3.35×10−10 | 2.226 | 1.734 | 2.858 |
| Tumor number (multiple vs. single) | 7.16×10−3 | 1.360 | 1.087 | 1.702 |
| Vascular invasion (yes vs. no) | 4.03×10−9 | 1.938 | 1.555 | 2.416 |
| Extrahepatic metastasis (yes vs. no) | 9.46×10−3 | 1.639 | 1.129 | 2.381 |
| Tumor differentiation (III–IV vs. I–II) | 9.54×10−3 | 1.267 | 1.059 | 1.516 |
| Tumor encapsulation (none vs. complete) | 7.14×10−5 | 1.433 | 1.200 | 1.711 |
| Genotype (AA vs. AG+GG) | 8.61×10−3 | 0.713 | 0.554 | 0.918 |
| For rs34675408 | ||||
| AFP, ng/ml (>20 vs. ≤20) | 0.046 | 1.210 | 1.004 | 1.458 |
| Tumor size, cm (>5 vs. ≤5) | 1.47×10−9 | 2.145 | 1.675 | 2.747 |
| Tumor number (multiple vs. single) | 0.016 | 1.315 | 1.053 | 1.644 |
| Vascular invasion (yes vs. no) | 2.29×10−10 | 2.033 | 1.632 | 2.531 |
| Extrahepatic metastasis (yes vs. no) | 4.29×10−3 | 1.722 | 1.186 | 2.499 |
| Tumor differentiation (III–IV vs. I–II) | 4.45×10−3 | 1.294 | 1.084 | 1.547 |
| Tumor encapsulation (none vs. complete) | 1.04×10−4 | 1.417 | 1.188 | 1.689 |
| Genotype (GT vs. TT) | 2.37×10−5 | 1.863 | 1.396 | 2.486 |
| For rs6078460 | ||||
| AFP, ng/ml (>20 vs. ≤20) | 0.051 | 1.205 | 0.999 | 1.452 |
| Tumor size, cm (>5 vs. ≤5) | 7.91×10−11 | 2.289 | 1.783 | 2.938 |
| Tumor number (multiple vs. single) | 3.15×10−3 | 1.402 | 1.120 | 1.754 |
| Vascular invasion (yes vs. no) | 6.03×10−10 | 2.001 | 1.607 | 2.493 |
| Extrahepatic metastasis (yes vs. no) | 4.20×10−3 | 1.726 | 1.188 | 2.507 |
| Tumor differentiation (III–IV vs. I–II) | 0.015 | 1.248 | 1.044 | 1.493 |
| Tumor encapsulation (none vs. complete) | 2.85×10−4 | 1.393 | 1.165 | 1.666 |
| Genotype (AA vs. AG+GG) | 8.95×10−3 | 1.258 | 1.059 | 1.494 |
| For rs6766361 | ||||
| AFP, ng/ml (>20 vs. ≤20) | 0.034 | 1.224 | 1.016 | 1.474 |
| Tumor size, cm (>5 vs. ≤5) | 4.17×10−10 | 2.219 | 1.728 | 2.849 |
| Tumor number (multiple vs. single) | 4.19×10−3 | 1.387 | 1.109 | 1.736 |
| Vascular invasion (yes vs. no) | 3.66×10−9 | 1.935 | 1.554 | 2.410 |
| Extrahepatic metastasis (yes vs. no) | 9.68×10−3 | 1.635 | 1.127 | 2.373 |
| Tumor differentiation (III–IV vs. I–II) | 9.25×10−3 | 1.268 | 1.060 | 1.517 |
| Tumor encapsulation (none vs. complete) | 4.66×10−5 | 1.444 | 1.210 | 1.724 |
| Genotype (AA+CA vs. CC) | 1.04×10−3 | 0.751 | 0.633 | 0.891 |
SNP – single nucleotide polymorphisms; HCC – hepatocellular carcinoma; AFP – alpha-fetoprotein; CI – confidence interval; HR – hazard ratio.