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. 2019 Apr 5;10:667. doi: 10.3389/fmicb.2019.00667

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Copyright © 2019 Uka, Moore, Arroyo-Manzanares, Nebija, De Saeger and Diana Di Mavungu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heat map representing metabolite distribution in 55 A. flavus isolates. On the top of the figure, a dendogram is depicted, clustering A. flavus isolates as function of mating-type genes (MAT1-1 and MAT1-2) and metabolite occurrence. This figure was generated using the online metabolomics platform MetaboAnalyst 3.0 after the data were treated accordingly using sum normalization, log transformations and Pareto scaling. The data table was prepared using area under the curve (AUC) for each chromatographic peak of respective metabolites. Anq, anthraquinones; PKs, polyketides; NRPs, non-ribosomal peptides; IND-DITs, indole-diterpenoids; ST, sterigmatocystin; OMST, O-methylsterigmatocystin; DHST, dihydro-ST; DHOMST, dihydro-OMST; Asparas., asparasone A; Asper. OCH_3, asperentin methyl-ether; 6,8-DMCIC, 6,8-dimethylcitreoisocoumarin; Asp. acid, aspergillic acid; Neoasp. acid, neoaspergillic acid; α-CPA, alfa-cyclopiazonic acid; Lep. B, leporin B.