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. 2019 Apr 9;7:e6629. doi: 10.7717/peerj.6629

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©2019 Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) The volcano map shows 310 upregulated genes and 665 downregulated genes in A549-HOXC6 cells in comparison to A549-NEO cells, and 112 upregulated genes and 385 downregulated genes in PC9-HOXC6 cells in comparison to PC9-NEO cells. Log2 fold change (Log2FC) >1 or <−1, and P < 0.05 were considered to be statistically significant. (B) Gene ontology (GO) analysis identified biological processes impacted by HOXC6-regulated genes in NSCLC cells. (C) Overlap of upregulated and downregulated genes in A549-HOXC6 and PC9-HOXC6 cells.