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. 2019 Apr 12;15(4):e8250. doi: 10.15252/msb.20188250

Figure 4. INKA analysis of three oncogene‐driven cancer cell line from the literature.

Figure 4

  1. H3255 NSCLC cells with an EGFR mutation. INKA analysis shows that EGFR is a hyper‐activated kinase (top 2 in all branches), together with MET.
  2. A204 rhabdomyosarcoma cells with documented PDGFRA signaling. PDGFRA exhibits variable ranking (top to intermediate) in individual analysis types for A204, but integrated INKA analysis (right‐most bar graph) infers it as a highly active, rank‐2 kinase, after EPHA1.
  3. MNNG/HOS osteosarcoma cells with documented MET signaling. MET consistently ranks among the top 2 in all analysis arms, culminating in a first rank in the integrative INKA analysis.
Data information: See the legend of Fig 2 for basic explanation.