Table 1.

Affinity between fibrillin-1 or tropoelastin and their binding proteins with the protein interaction analysis approach (SPR = surface plasmon resonance, IP = immunoprecipitation, Solid Phase = solid phase binding assay) and dissociation constant (Kd).

Protein A	Protein B	Reference	Approach	Kd (nM)
FBN1 N-ter	ADAMTS10	[17,18,19]	SPR	11-35; 245
FBN1 N-ter	ADAMTS6	[18]	SPR	1-7
FBN1 N-ter	ADAMTSL2	[19]	SPR	200
FBN1 N-ter	ADAMTSL3	[19]	SPR	6
FBN1 N-half	ADAMTSL5	[20]	IP	N/A
FBN1 N-half	ADAMTSL6β	[21]	SPR	80
FBN1 N-half	Aggrecan	[22]	SPR	49 and 42
FBN1 cbEGF22-TB4-cbEGF23	Integrin αVβ6	[3]	SPR	1
FBN1 N-ter	BMP-2, 4, 5, 7, 10, GDF5	[23,24]	SPR	6 - 34
FBN1 N-ter	Brevican, Neurocan, Versican	[22]	SPR	20, 2, 7.1
FBN1 N-ter	Calsyntenin-1	[25]	SPR	240
FBN1 N- and C-ter	FBN1	[26]	Solid Phase	5-11
FBN1 N-ter	FBN1 C-ter	[27]	SPR	3-25
FBN1 N-ter	FBN2 C-ter	[27]	SPR	10-74
FBN1 N-ter	Fibulin-2	[28]	SPR	160
FBN1 N-ter	Fibulin-4	[28,29]	SPR	74; 54
FBN1 N-ter	Fibulin-5	[28,29]	Solid Phase, SPR	63; 23
FBN1 C-half	Fibronectin	[30]	SPR	55
FBN1 N- and C-ter	Heparan Sulphate	[30,31]	SPR	27, 93; 16
FBN1 N-ter	LTBP1	[28]	SPR	21
FBN1 N-ter	LTBP2	[32]	Solid Phase	22
FBN1 N-ter	LTBP-4	[28]	SPR	24
FBN1 N-ter	Lysyl Oxidase	[29]	Solid Phase	26
FBN1 N-ter	MAGP1	[31,33]	SPR, Solid Phase	140-240; 36.5
FBN1 N-half	Perlecan	[34]	SPR	6-9
FBN1 N-ter	MFAP4	[35]	SPR	N.D.
Tropoelastin	Biglycan	[36]	Solid Phase	195
Tropoelastin	FBN1 N-ter, Mid, C-ter	[31,33]	SPR	280, 5; 27
Tropoelastin	Fibulin-1C	[37]	SPR	18
Tropoelastin	Fibulin-2	[38]	Solid Phase	1-2
Tropoelastin	Fibulin-2	[37]	SPR	18
Tropoelastin	Fibulin-4	[29,38]	Solid Phase	8, 131
Tropoelastin	Fibulin-5	[29,38]	Solid Phase; SPR	2; 64
Tropoelastin	Lysyl Oxidase	[29]	Solid Phase	49
Tropoelastin	MAGP1	[33]	SPR	22
Tropoelastin	Perlecan	[37]	SPR	21