Table 2.
Correlations Between Changes in Blood Biomarker Levels Over the Course of the Study
| D-dimer | CRP | IL-8 | TNF-α | sCD163 | sCD14 | I-FABP | |
|---|---|---|---|---|---|---|---|
| A. Absolute Values | |||||||
| D-dimer | N/A | 0.51 (0.002*) | 0.00 (0.98) | 0.21 (0.23) | 0.26 (0.15) | −0.05 (0.80) | −0.35 (0.044*) |
| CRP | 0.51 (0.002*) | N/A | 0.28 (0.11) | 0.30 (0.087) | −0.01 (0.97) | 0.16 (0.37) | 0.13 (0.47) |
| IL-8 | 0.00 (0.98) | 0.28 (0.11) | N/A | 0.28 (0.12) | −0.04 (0.82) | 0.26 (0.12) | 0.36 (0.035*) |
| TNF-α | 0.21 (0.23) | 0.30 (0.087) | 0.28 (0.12) | N/A | 0.51 (0.002*) | 0.34 (0.050*) | 0.12 (0.49) |
| sCD163 | 0.26 (0.15) | −0.01 (0.97) | −0.04 (0.82) | 0.51 (0.002*) | N/A | 0.31 (0.078) | −0.13 (0.46) |
| sCD14 | −0.05 (0.80) | 0.16 (0.37) | 0.26 (0.12) | 0.34 (0.050*) | 0.31 (0.078) | N/A | 0.11 (0.52) |
| I-FABP | −0.35 (0.044*) | 0.13 (0.47) | 0.36 (0.035*) | 0.12 (0.49) | −0.13 (0.46) | 0.11 (0.52) | N/A |
| B. Changes in Values | |||||||
| D-dimer | N/A | 0.84 (0.00002*) | 0.08 (0.77) | −0.26 (0.31) | −0.14 (0.59) | 0.62 (0.008*) | 0.03 (0.90) |
| CRP | 0.84 (0.00002*) | N/A | 0.12 (0.64) | −0.15 (0.56) | −0.12 (0.65) | 0.65 (0.004*) | 0.33 (0.20) |
| IL-8 | 0.08 (0.77) | 0.12 (0.64) | N/A | 0.11 (0.69) | −0.39 (0.13) | 0.10 (0.71) | 0.07 (0.78) |
| TNF-α | −0.26 (0.31) | −0.15 (0.56) | 0.11 (0.69) | N/A | −0.28 (0.27) | −0.50 (0.042*) | −0.06 (0.82) |
| sCD163 | −0.14 (0.59) | −0.12 (0.65) | −0.39 (0.13) | −0.28 (0.27) | N/A | −0.26 (0.30) | 0.46 (0.065) |
| sCD14 | 0.62 (0.008*) | 0.65 (0.004*) | 0.10 (0.71) | −0.50 (0.042*) | −0.26 (0.30) | N/A | 0.02 (0.94) |
| I-FABP | 0.03 (0.90) | 0.33 (0.20) | 0.07 (0.78) | −0.06 (0.82) | 0.46 (0.065) | 0.02 (0.94) | N/A |
For each of the listed biomarkers, Spearman rank correlation rho values (p-value) are given for (A) intraindividual comparisons of blood levels including both time points at the start and finish of the study and (B) intraindividual comparisons of changes of blood levels between the start and finish of placebo/probiotic administration.
CRP, C-reactive protein; IL, interleukin; TNF, tumor necrosis factors sCD163, soluble CD163; sCD14, soluble CD14; I-FABP, intestinal-type fatty acid binding protein.
*
p≤0.05.