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. 2016 Jul 14;2016(7):CD011352. doi: 10.1002/14651858.CD011352.pub2

Comparison 4.

NSAID versus a different dose of the same NSAID

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Adequate pain relief (4 hours after administration) 9 Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 Ibuprofen 300 mg to 400 mg (A) versus Ibuprofen 800 mg (B) 1 160 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.63, 1.58]
1.2 Diflunisal 125 mg (A) versus Diflunisal 250 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 1.21 [0.60, 2.46]
1.3 Diflunisal 125 mg (A) versus Diflunisal 500 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.78 [0.43, 1.41]
1.4 Diflunisal 250 mg (A) versus Diflunisal 500 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 0.64 [0.33, 1.25]
1.5 Meclofenamate sodium 100 mg (A) versus Meclofenamate sodium 200 mg (B) 3 348 Risk Ratio (M‐H, Fixed, 95% CI) 1.00 [0.85, 1.17]
1.6 Diclofenac 25 mg (A) versus Diclofenac 50 mg (B) 1 102 Risk Ratio (M‐H, Fixed, 95% CI) 0.90 [0.68, 1.21]
1.7 Diclofenac 25 mg (A) versus Diclofenac 100 mg (B) 1 103 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.65, 1.11]
1.8 Ketoprofen 25 mg (A) versus Ketoprofen 50 mg (B) 1 54 Risk Ratio (M‐H, Fixed, 95% CI) 1.03 [0.73, 1.46]
1.9 Aceclofenac 50 mg (A) versus Aceclofenac 100 mg (B) 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.65, 1.54]
1.10 Aceclofenac 50 mg (A) versus Aceclofenac 150 mg (B) 1 39 Risk Ratio (M‐H, Fixed, 95% CI) 0.82 [0.56, 1.21]
1.11 Aceclofenac 100 mg (A) versus Aceclofenac 150 mg (B) 1 45 Risk Ratio (M‐H, Fixed, 95% CI) 0.82 [0.58, 1.17]
1.12 Flurbiprofen 25 mg (A) versus Flurbiprofen 50 mg (B) 1 61 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.37, 1.20]
1.13 Flurbiprofen 25 mg (A) versus Flurbiprofen 50 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.71 [0.39, 1.30]
1.14 Flurbiprofen 50 mg (A) versus Flurbiprofen 100 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [0.64, 1.77]
2 Adequate pain relief (6 hours after administration) 11 Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 Ibuprofen 300 mg to 400 mg (A) versus Ibuprofen 900 mg (B) 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.77, 1.30]
2.2 Diflunisal 125 mg (A) versus Diflunisal 250 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 1.18 [0.61, 2.29]
2.3 Diflunisal 125 mg (A) versus Diflunisal 500 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.74 [0.43, 1.27]
2.4 Diflunisal 250 mg (A) versus Diflunisal 500 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 0.63 [0.34, 1.15]
2.5 Meclofenamate sodium 100 mg (A) versus Meclofenamate sodium 200 mg (B) 3 348 Risk Ratio (M‐H, Fixed, 95% CI) 1.00 [0.84, 1.18]
2.6 Ketoprofen 25 mg (A) versus Ketoprofen 50 mg (B) 1 54 Risk Ratio (M‐H, Fixed, 95% CI) 0.98 [0.66, 1.46]
2.7 Aceclofenac 50 mg (A) versus Aceclofenac 100 mg (B) 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.93 [0.69, 1.27]
2.8 Aceclofenac 50 mg (A) versus Aceclofenac 150 mg (B) 1 39 Risk Ratio (M‐H, Fixed, 95% CI) 0.86 [0.65, 1.14]
2.9 Aceclofenac 100 mg (A) versus Aceclofenac 150 mg (B) 1 45 Risk Ratio (M‐H, Fixed, 95% CI) 0.92 [0.73, 1.16]
2.10 Etodolac 25 mg (A) versus Etodolac 100 mg (B) 1 80 Risk Ratio (M‐H, Fixed, 95% CI) 0.73 [0.39, 1.39]
2.11 Flurbiprofen 25 mg (A) versus Flurbiprofen 50 mg (B) 1 61 Risk Ratio (M‐H, Fixed, 95% CI) 0.65 [0.39, 1.09]
2.12 Flurbiprofen 25 mg (A) versus Flurbiprofen 100 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.40, 1.10]
2.13 Flurbiprofen 50 mg (A) versus Flurbiprofen 100 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 1.01 [0.68, 1.51]
2.14 Fenoprofen 50 mg (A) versus Fenoprofen 100 mg (B) 2 100 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.62, 1.16]
2.15 Fenoprofen 50 mg (A) versus Fenoprofen 200 mg (B) 2 99 Risk Ratio (M‐H, Fixed, 95% CI) 0.86 [0.62, 1.17]
2.16 Fenoprofen 50 mg (A) versus Fenoprofen 300 mg (B) 1 54 Risk Ratio (M‐H, Fixed, 95% CI) 0.89 [0.61, 1.31]
2.17 Fenoprofen 100 mg (A) versus Fenoprofen 200 mg (B) 2 99 Risk Ratio (M‐H, Fixed, 95% CI) 1.01 [0.76, 1.34]
2.18 Fenoprofen 100 mg (A) versus Fenoprofen 300 mg (B) 1 53 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.74, 1.46]
2.19 Fenoprofen 200 mg (A) versus Fenoprofen 300 mg (B) 1 53 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.74, 1.46]
2.20 Fenoprofen 12.5 mg (A) versus Fenoprofen 25 mg (B) 1 47 Risk Ratio (M‐H, Fixed, 95% CI) 0.87 [0.46, 1.65]
2.21 Fenoprofen 12.5 mg (A) versus Fenoprofen 50 mg (B) 1 47 Risk Ratio (M‐H, Fixed, 95% CI) 0.87 [0.46, 1.65]
2.22 Fenoprofen 12.5 mg (A) versus Fenoprofen 100 mg (B) 1 47 Risk Ratio (M‐H, Fixed, 95% CI) 0.64 [0.37, 1.12]
2.23 Fenoprofen 12.5 mg (A) versus Fenoprofen 200 mg (B) 1 47 Risk Ratio (M‐H, Fixed, 95% CI) 0.74 [0.41, 1.33]
2.24 Fenoprofen 25 mg (A) versus Fenoprofen 50 mg (B) 1 46 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.55, 1.83]
2.25 Fenoprofen 25 mg (A) versus Fenoprofen 100 mg (B) 1 46 Risk Ratio (M‐H, Fixed, 95% CI) 0.73 [0.44, 1.23]
2.26 Fenoprofen 25 mg (A) versus Fenoprofen 200 mg (B) 1 46 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.48, 1.48]
3 Need for additional analgesia (4 hours after administration) 1 Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1 Ibuprofen 300 mg to 400 mg (A) versus Ibuprofen 800 mg (B) 1 160 Risk Ratio (M‐H, Fixed, 95% CI) 0.57 [0.17, 1.88]
4 Need for additional analgesia (6 hours after administration) 4 Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.1 Ibuprofen 300 mg to 400 mg (A) versus Ibuprofen 900 mg (B) 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 3.0 [0.13, 69.52]
4.2 Meclofenamate sodium 100 mg (A) versus Meclofenamate sodium 200 mg (B) 2 191 Risk Ratio (M‐H, Fixed, 95% CI) 0.91 [0.55, 1.50]
4.3 Flurbiprofen 25 mg (A) versus Flurbiprofen 50 mg (B) 1 61 Risk Ratio (M‐H, Fixed, 95% CI) 2.73 [0.12, 64.42]
4.4 Flurbiprofen 25 mg (A) versus Flurbiprofen 100 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 2.91 [0.12, 68.81]
4.5 Flurbiprofen 50 mg (A) versus Flurbiprofen 100 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Maternal drug adverse effects (4 hours after administration) 2 Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 Diflunisal 125 mg (A) versus Diflunisal 250 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 Diflunisal 125 mg (A) versus Diflunisal 500 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.3 Diflunisal 250 mg (A) versus Diflunisal 500 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.4 Ibuprofen 300 mg to 400 mg (A) versus Ibuprofen 800 mg (B) 1 160 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Maternal drug adverse effects (6 hours after administration) 5 Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
6.1 Ibuprofen 300 mg (A) versus Ibuprofen 900 mg (B) 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.23, 4.37]
6.2 Diflunisal 125 mg (A) versus Diflunisal 250 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.3 Diflunisal 125 mg (A) versus Diflunisal 500 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.4 Diflunisal 250 mg (A) versus Diflunisal 500 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.5 Ketoprofen 25 mg (A) versus Ketoprofen 50 mg (B) 1 54 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.6 Aceclofenac 50 mg (A) versus Aceclofenac 100 mg (B) 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 3.95 [0.17, 91.61]
6.7 Aceclofenac 50 mg (A) versus Aceclofenac 150 mg (B) 1 39 Risk Ratio (M‐H, Fixed, 95% CI) 3.47 [0.15, 80.35]
6.8 Aceclofenac 100 mg (A) versus Aceclofenac 150 mg (B) 1 45 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.9 Flurbiprofen 25 mg (A) versus Flurbiprofen 100 mg (B) 1 61 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.10 Flurbiprofen 25 mg (A) versus Flurbiprofen 100 mg (B) 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.11 Flurbiprofen 50 mg (A) versus Flurbiprofen 100 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]