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. 2019 Mar 29;29(2):82–91. doi: 10.1089/nat.2018.0754

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© Jason D. Ferrone et al. 2019: Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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FIG. 1. — IONIS-PKK_Rx reduces expression of human mRNA in HepaRG human hepatoma cells and transgenic mice. (A) IONIS-PKK_Rx inhibits PKK mRNA expression in HepaRG human hepatoma cells. Data are presented as mean ± SEM (N = 3). Control ASO sequence: 5′-CCTTCCCTGAAGGTTCCTCC-3′; underline denotes 2′MOE-modified nucleotides. (B) Liver hPKK mRNA expression in hPKK-Tg mice after 3 weeks of IONIS-PKK_Rx treatment. (C) Plasma hPKK levels in hPKK-Tg mice after 3 weeks of IONIS-PKK_Rx treatment. ASO, antisense oligonucleotides; hPKK-Tg, human PKK transgenic; 2′MOE, 2′-O-(2-methoxyethyl).