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. 2019 Mar 29;29(2):82–91. doi: 10.1089/nat.2018.0754

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© Jason D. Ferrone et al. 2019: Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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FIG. 2. — IONIS-PKK_Rx reduces hepatic PKK mRNA and serum PKK protein levels in Cynomolgus monkeys. (A) Reduction of hepatic PKK mRNA expression in Cynomolgus monkeys after 16 weeks of treatment with IONIS-PKK_Rx as a percent of saline treated_. Data points represent individual animals with mean ± SEM. Significant difference from PBS by one-way ANOVA with Dunnett's post-test (*P < 0.05, ***P < 0.001). (B) Time- and dose-dependent reduction of plasma PKK protein levels in Cynomolgus monkeys over 16 weeks of treatment with IONIS-PKK_Rx. Data are presented as mean ± SEM. PBS, phosphate-buffered saline.