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. 2019 Mar 29;29(2):82–91. doi: 10.1089/nat.2018.0754

Table 1.

Sequence of IONIS-PKKRx-Binding Sites Across Different Species

IONIS-PKKRx 5′ TGCAAGTCTCTTGGCAAACA 3′
Human RNA 3′ ACGTTCAGAGAACCGTTTGT 5′
Cynomolgus RNA 3′ ATGTTCAGAGAACCGTTTGT 5′
Rhesus RNA 3′ ATGTTCAGAGAACCGTTTGT 5′
Baboon RNA 3′ ATGTTCAGAGAACCGTTTGT 5′

Underline denotes 2′MOE-modified nucleotides; all cytosines are methylated at the 5-position. Nucleotide in italics denotes mismatch in Monkey mRNA.

2′MOE, 2′-O-(2-methoxyethyl).