2.1. Analysis.
Comparison 2 Anaesthesia depth monitors (BIS) versus standard clinical and electronic monitoring, Outcome 1 Definite and possible awareness (Grade 4).
| Definite and possible awareness (Grade 4) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Study |
ADM Events |
N |
SCP Events |
N | OR 95% CI |
Alarms/alerts ‐‐‐‐‐‐‐‐‐‐‐‐‐‐ Inhalation vs TIVA |
Subgroups ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ Summary OR 95% CI |
Totals ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ Summary OR 95% CI; P value I2; heterogeneity P value Subgroup interaction P value |
| Avidan 2008 | 6 | 967 | 3 | 974 | 2.02 (0.50 to 8.10) | Alarms ‐‐‐‐‐‐‐‐ Inhalation |
— | — |
| Avidan 2011 | 20 | 2861 | 8 | 2852 | 2.50 (1.10 to 5.69) | Alarms ‐‐‐‐‐‐‐‐ Inhalation |
— | — |
| Mashour 2012 | 18 | 9460 | 19 | 9376 | 0.94 (0.49 to 1.79) | Alarms and alerts ‐‐‐‐‐‐‐‐‐‐‐‐‐ Inhalation |
Alarms and/or alerts inhalational ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ 1.51 (0.45 to 5.07) |
— |
| Myles 2004 | 22 | 1225 | 27 | 1238 | 0.82 (0.46 to 1.45) | None ‐‐‐‐‐‐‐‐‐‐‐ Majority TIVA |
— | — |
| Zhang 2011 | 8 | 2919 | 21 | 2309 | 0.30 (0.13 to 0.68) | None ‐‐‐‐‐‐‐‐‐‐‐‐‐ Exclusively TIVA |
No alarms TIVA ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ 0.55 (0.15 to 1.96) |
74/17,432 vs 78/16,749 ‐‐‐‐‐‐‐‐‐‐‐‐‐‐ 0.96 (0.35 to 2.65); P = 0.93 I2 = 68%; P = 0.01; P = 0.17 (subgroup) |