Ghaly 1988.
Methods | Study design: randomized parallel groups Study dates: not stated | |
Participants | Country: England Sex: female Age: 28 Procedure: elective caesarean section for cephalopelvic disproportion Study size: 50 |
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Interventions |
Randomized portion of anaesthetic: parts of volatile agent Intervention 1: maintenance: halothane 0.5%, N = 25 Intervention 2: maintenance: Isoflurane 0.75%, N = 25 |
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Outcomes | Primary outcomes: anaesthesia recovery, APGAR scores, blood gases Secondary outcome: awareness/wakefulness as defined using an awareness classification system (see Table 1): class 1 Comment: none of the mothers complained of intraoperative dreams or awareness |
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Notes |
Non‐randomized portion of anaesthetic: parts of volatile agent N2O yes/narcotics/hypnotics bolus/muscle relaxants induction yes/maintenance yes Anaesthesia induction: thiopentone (3 mg to 5 mg/kg) + suxamethonium 100 mg. Anaesthesia maintenance: 50:50 N2O:O2 + group‐specific volatile agent; post‐delivery: alfentaniI 1.0 mg IV/N2O 70%/suxamethonium 0.1% rate just sufficient to abolish diaphragmatic movement Time of outcome determination: first postoperative day Method of outcome determination: interview No email address available for ROB survey |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "They were randomly allocated to either the isoflurane or halothane group" |
Allocation concealment (selection bias) | Unclear risk | Comment: no information provided |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Comment: anaesthesiologist: no information provided |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Comment: assessor: no information provided |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: no missing outcome data |
Selective reporting (reporting bias) | Low risk | Comment: awareness outcome part of inclusion criteria |
Other bias | Unclear risk | Comment: insufficient information provided |