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. 2016 Oct 18;2016(10):CD007272. doi: 10.1002/14651858.CD007272.pub2

Ghaly 1988.

Methods Study design: randomized parallel groups
 Study dates: not stated
Participants Country: England
Sex: female
Age: 28
Procedure: elective caesarean section for cephalopelvic disproportion
Study size: 50
Interventions Randomized portion of anaesthetic: parts of volatile agent
Intervention 1: maintenance: halothane 0.5%, N = 25
Intervention 2: maintenance: Isoflurane 0.75%, N = 25
Outcomes Primary outcomes: anaesthesia recovery, APGAR scores, blood gases
Secondary outcome: awareness/wakefulness as defined using an awareness classification system (see Table 1): class 1
Comment: none of the mothers complained of intraoperative dreams or awareness
Notes Non‐randomized portion of anaesthetic: parts of volatile agent N2O yes/narcotics/hypnotics bolus/muscle relaxants induction yes/maintenance yes
Anaesthesia induction: thiopentone (3 mg to 5 mg/kg) + suxamethonium 100 mg. Anaesthesia maintenance: 50:50 N2O:O2 + group‐specific volatile agent; post‐delivery: alfentaniI 1.0 mg IV/N2O 70%/suxamethonium 0.1% rate just sufficient to abolish diaphragmatic movement
Time of outcome determination: first postoperative day
Method of outcome determination: interview
No email address available for ROB survey
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "They were randomly allocated to either the isoflurane or halothane group"
Allocation concealment (selection bias) Unclear risk Comment: no information provided
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Comment: anaesthesiologist: no information provided
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: assessor: no information provided
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: no missing outcome data
Selective reporting (reporting bias) Low risk Comment: awareness outcome part of inclusion criteria
Other bias Unclear risk Comment: insufficient information provided